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Available evidence is primarily observational or from cell culturenot conclusive for clinical outcomes

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Benefits of Prolotherapy for Slipping Rib Syndrome When performed properly, prolotherapy may: Improve rib stability and reduce subluxation Decrease intercostal nerve irritation Relieve chronic rib, chest, and upper abdominal pain Improve breathing comfort Restore normal movement patterns Reduce or eliminate the need for surgery Most patients undergo a series of treatments spaced several weeks apart, with gradual improvement over the course of care

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Compared to the negative control group, positive TUNEL staining cells began decreasing at 7 days and few apoptotic cells were observed at 10 days in FOXO4-DRI (25 M) addition group